Publish or Perish :)

  1. Johnstone, M. A. Si, A.; Landgraf, A. D.; Sucheck, S. J.; Self. W. T. Evaluation of Derivatives of (+)-Puupehenone against Clostridioides difficile and Other Gram-Positive Bacteria. 2022 https://doi.org/10.1021/acsomega.2c04471.

  2. Thanvi, R.; Jayasinghe, T. D.; Sunayana, K.; Obadawo1, B.S.; Ronning, D.R.; and Sucheck, S.J. Synthesis of C7/C8-cyclitols and C7N-aminocyclitols from maltose and X-ray Structure of a Streptomyces coelicolor GlgEI V279S in complex with an Amylostatin GXG-like derivative. Front. Chem. 2022, https://doi.org/10.3389/fchem.2022.950433.

  3. Si, A.; Landgraf, A. D.; Sucheck, S. J.; Rohde, K.H. Synthesis and evaluation of marine natural product-inspired meroterpenoids with selective activity towards dormant Mycobacterium tuberculosis ACS Omega 2022, 7, 23487–23496. https://doi.org/10.1021/acsomega.2c01887

  4. Si, A. and Sucheck, S. J. Front. Mol. Biosci. Synthesis of aminooxy glycoside derivatives of the outer core domain of Pseudomonas aeruginosa lipopolysaccharide. Front. Mol. Biosci. 2021 Accepted. doi: 10.3389/fmolb.2021.750502

  5. Khan, S. S.; Sudasinghe, T. D.; Landgraf, A. D.; Ronning, D. R.; Sucheck, S. J. Total synthesis of tetrahydrolipstatin, its derivatives, and evaluation of their ability to potentiate multiple antibiotic classes against Mycobacterium species. ACS Infect. Dis. Article 2021 ASAP DOI: 10.1021/acsinfecdis.1c00283

  6. Si, A.; Jayasinghe, T.D.; Thanvi, R.; Ronning, D. R.; Sucheck, S. J. Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S. Sci. Rep. 2021, 11, 13413. https://doi.org/10.1038/s41598-021-92554-9

  7. Landgraf, A. D.; Alsegiani, A. S.; Alaqel, S.; Thanna, S.; Shah Z. A.; Sucheck, S. J. Neuroprotective and anti-neuroinflammatory properties of ebselen derivatives and their potential to inhibit neurodegeneration. ACS Chem Neurosci. 2020, doi.org/10.1021/acschemneuro.0c00328

  8. Hossain, M. K.; Vartak, A.; Sucheck, S. J; Wall K.A. Synthesis and Immunological Evaluation of a Single Molecular Construct MUC1 Vaccine Containing l-Rhamnose Repeating Units. Molecules 2020, 25, 3137. doi.org/10.3390/molecules25143137

  9. Thanvi, R.; Kapil S.; and Sucheck, S. J. Strategies for Developing Carbohydrates as Glycoside Hydrolase Inhibitors. 2020. Accepted, In press.

  10. Nandedkar-Kulkarni, N.; Vartak, A.; Sucheck, S. J.; Wall, K.; Quinn, A.; Morran, M.; McInerney, M. Development of a bioconjugate platform for modifying the immune response of autoreactive cytotoxic T lymphocytes involved in type 1 diabetes. Bioconj. Chem. 2019, 30, 2049–2059 DOI: 10.1021/acs.bioconjchem.9b00332

  11. Vartak, A.; Goins, C.; Nogueira de Moura, V. C.; Schreidah, C. M.; Landgraf, A. D.; Lin B.; Du, J.; Jackson, M.; Ronning D. R.; Sucheck S. J. Biochemical and microbiological evaluation of N-aryl urea derivatives against Mycobacteria and Mycobacterial hydrolases. MedChemComm, 2019, 10, 1197–1204, DOI: 10.1039/C9MD00122K

  12. Hossain, M. K.; Vartak, A.; Sucheck, S. J; Wall. K.A. A liposomal Fc domain conjugated to a cancer vaccine enhances both humoral and cellular immunity. ACS Omega, 2019, 4, 5204–5208. PMCID: PMC6441943, doi: 10.1021/acsomega.9b00029.

  13. Kapil, S.; Petit, C.; Drago, V. N.; Ronning, D. R.; Sucheck, S. J. Synthesis and in vitro characterization of trehalose‐based inhibitors of mycobacterial trehalose 6‐phosphate phosphatases. ChemBiochem 2019, 20, 260–269. PMCID: PMC6467533. doi: 10.1002/cbic.201800551

  14. Hossain, M. K.; Vartak, A.; Karmakar, P.; Sucheck, S. J. and K. A. Wall. Augmenting vaccine immunogenicity through the use of natural human anti-rhamnose antibodies. ACS Chem. Biol. 2018, 13, 2130–2142. doi: 10.1021/acschembio.8b00312.

  15. Vartak, A. and Sucheck, S. J. Advances in synthetic approaches towards glycoantigens. In Carbohydrate-Based Vaccines: From Concept to Clinic; A. Krishna Prasad, Ed.; ACS Symposium Series 1290; American Chemical Society: Washington, DC, 2018; pp175-195; ISBN13: 9780841233379; doi: 10.1021/bk-2018-1290.ch008

  16. Vartak, A.; Hefny, F. M.; Sucheck, S. J. Synthesis of Oligosaccharide components of the outer core domain of P. aeruginosa lipopolysaccharide using a multifunctional hydroquinone-derived reducing-end capping group. Org. Lett. 2018, 20, 353−356. doi:10.1021/acs.orglett.7b03590

  17. Veleti, S. K.; Petit, C.; Ronning, D. R.; Sucheck, S. J. Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S Org. Biomol. Chem., 2017, 15, 3884–3891. doi: 10.1039/C7OB00388A (Hot Article) PMID: 28422240. Author Correction: Veleti, S. K.; Petit, C.; Lindenberger, J. J.; Ronning, D. R.; Sucheck, S. J. Org. Biomol. Chem., doi: 10.1039/C7OB90121F

  18. Goins, C. M.; Thanna, S, Dajnowicz, S.; Sucheck, S. J.; Parks, J. M.; Ronning, D. R. Exploring covalent allosteric inhibition of Antigen 85C from Mycobacterium tuberculosis by ebselen derivatives. ACS Infect. Dis., 2017, 3, 378–387. doi: 10.1021/acsinfecdis.7b00003 PMID: 28285521

  19. Thanna, S.; Goins, C. M.; Knudson, S. E.; Slayden, R. A.; Ronning, D. R ; Sucheck S. J. Thermal and photoinduced copper-promoted C−Se bond formation: Synthesis of 2-alkyl-1,2-benzisoselenazol-3(2H)ones and evaluation against Mycobacterium tuberculosis J. J. Org. Chem., 2017, 82, 3844–3854. doi: 10.1021/acs.joc.7b00440 PMID: 28273423

  20. Sucheck, S. J. Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycosciences. Eds Z. J. Witczak and R. Bielski. Angew. Chem. Int. Ed. 2016, 55, 11337–11338. Book Review. doi: 10.1002/anie.201606642

  21. Veleti S. K. and Sucheck, S. J. Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE. In Strategies for coupling and decoupling diverse molecular units in the glycosciences; Witczak, Z. J., Bielski, R., Eds.; Wiley: New Jersey, in press

  22. Thanna, S.; Knudson, S. E.; Grezegorzewic, A.; Kapil, S.; Goins, C. M.; Ronning, D. R.; Jackson, M.; Slayden, R. A. Sucheck, S. J. Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis Org. Biomol. Chem., 2016, 14, 6119–6133. doi: 10.1039/C6OB00821F. PMID: 27251120

  23. Vartak, A. and Sucheck, S. J. Recent advances in subunit vaccine carriers. Vaccines (Basel) 2016, 4, 12. doi: 10.3390/vaccines4020012

  24. Thanna, S. and Sucheck S. J. Targeting the trehalose utilization pathways of Mycobacterium tuberculosis. Med. Chem. Commun., 2016, 7, 69–85. doi: 10.1039/C5MD00376H

  25. Karmakar, P.; Lee, K.; Sarkar, S.; Wall, K. A.; Sucheck, S. J. Synthesis of a liposomal MUC1 glycopeptide-based immunotherapeutic and evaluation of the effect of L-rhamnose targeting on cellular immune responses. Bioconjug Chem. 2016, 27,110–20.

  26. Lindenberger, J. J; Veleti, S. K.; Wilson, B.; Sucheck, S. J.; Ronning, D. R. Crystal structures of Mycobacterium tuberculosis GlgE and complexes with noncovalent inhibitors. Sci. Reports. 2015. DOI: 10.1038/srep12830.

  27. Giatonde, V. and Sucheck, S. J. Anti-tuberculosis drugs based on carbohydrate derivatives. In Carbohydrates Chemistry: State-of-the-art and challenges for drug development; Cipolla, L., Ed.; Imperial College Press: London, Aug 12, 2015. ISBN-10: 1783267194; ISBN-13: 978-1783267194.

  28. Thanna, S.; Lindenberger, J. J.; Vishwanath, G.; Ronning, D. R.; Sucheck, S. J. Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S. Org. Biomol. Chem. 2015, 13, 7542–7550.

  29. Veleti, S. K.; Lindenberger, J. J.; Thanna, S.; Ronning, D. R.; Sucheck, S. J. Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE. J. Org. Chem. 2014, 79, 9444–9450. PMID:25137149 (Feature Article)

  30. Long, D. E.; Karmakar P.; Wall, K. A.; Sucheck, S. J. Synthesis of α-L-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibodies. Bioorg. Med. Chem. 2014, 22, 5279–89. PMCID:PMC4172545

  31. Bouhall S. K and Sucheck, S. J. In situ preactivation strategies for the expeditious synthesis of oligosaccharides: A review. J. Carbohydr. Chem. 2014, 33, 347–367.

  32. Gaitonde, V.; Lee, K.; Kirschbaum, K.; Sucheck S. J. Bio-based bisfuran: synthesis, crystal structure, and low molecular weight amorphous polyester. Tetrahedron Lett. 2014, 55, 4141–4145. PMCID:PMC4096679

  33. Veleti, S. K.; Lindenberger, J. J.; Ronning, D. R.; Sucheck S. J. Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE. Bioorg. Med. Chem. 2014, 22, 1404–1411. PMCID:PMC4023634

  34. Sarkar, S.; Sayler, A. C. D.; Wall, K. A.; Sucheck, S. J. Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into L-rhamnose displaying liposomes. Bioconjugate. Chem. 2013, 24, 363–375. PMCID: PMC3623543

  35. Ibrahim, D. A.; Boucau, J.; Lajiness, D. H.; Veleti, S. K.; Trabbic, K. R.; Adams, S. S.; Ronning, D. R.; Sucheck S. J. Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chem. 2012, 23, 2403–2416. PMCID: PMC3548330

  36. Gaitonde, V. and Sucheck S. J. Synthesis of β-Glycosyl amides from N-glycosyl dinitrobenzenesulfonamides J. Carbohydr. Chem. 2012, 31, 433–450. PMCID:PMC3551597

  37. Karmakar, P.; Talan, S. R.; Sucheck, S. J. Mixed-phase synthesis of glycopeptides using a N-peptidyl-2,4-dinitrobenzenesulfonamide-thioacid ligation strategy. Org. Lett. 2011, 13, 5298–5301. PMCID: PMC3188410

  38. Sarkar, S.; Sucheck S. J. Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl and 2,4,6-trimethoxybenzyl as N–H protecting groups for p-tolyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-β-D-glucosides. Carbohydr. Res. 2011, 346, 393–400.

  39. Sarkar, S.; Lombardo, S. A.; Herner, D. N.; Talan, R. S.; Wall, K. A.; Sucheck S. J. Synthesis of a single molecule L-rhamnose-containing three component vaccine and evaluation of antigenicity in the presence of anti L-rhamnose antibodies. J. Am. Chem. Soc. 2010, 132, 17236–17246.

  40. Umesiri, F. E.; Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Recent advances towards the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med. Res. Rev. 2010, 30, 290–326.

  41. Talan, R. S.; Sanki, A. K.; Sucheck, S. J. Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids. Carbohydr. Res. 2009, 344, 2048–2050.

  42. Sanki, A. K.; Boucau, J.; Umesiri, F. E.; Ronning, D. R.; Sucheck, S. J. Design, synthesis and biological evaluation of sugar-derived esters, α-ketoesters and α-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Mol. BioSyst. 2009, 5, 945–956.

  43. Ragupathi, G.; Damani, P.; Srivastava, G.; Srivastava, O.; Sucheck, S. J.; Ichikawa, Y.; Livingston, P. O. Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine. Cancer Immunol. Immunother. 2009, 58, 1397–1405.

  44. Sanki, A. K.; Talan, R. S.; Sucheck, S. J. Synthesis of small glycopeptides by decarboxylative condensation and insight into the reaction mechanism. J. Org. Chem. 2009, 74, 1886–1896.

  45. Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconjugate J. 2009, 26, 589–596.

  46. Boucau J.; Sanki, A. K.; Voss, B. J.; Sucheck, S. J.; Ronning D. R. A coupled assay measuring Mycobacterium tuberculosis antigen 85C enzymatic activity. Anal. Biochem. 2009, 385, 120–127.

  47. Sanki A. K.; Boucau J.; Srivastava P.; Adams S. S.; Ronning, D. R., Sucheck, S. J Synthesis of methyl 5-S-alkyl-5-thio-arabinofuranosides and evaluation of their antimycobacterial activity. Bioorg. Med. Chem. 2008, 16, 5672–5682.

  48. Demaray, J. A.; Thuener, J. E.; Dawson, M. N.; Sucheck, S. J. Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity. Bioorg. Med. Chem. Lett. 2008, 18, 4868–4871.

  49. Liang, C. -H; Romero, A.; Rabuka, D.; Sgarbi, P. W. M.; Marby, K. A.; Duffield, J.; Yao, S.; Cheng, M. L; Ichikawa, Y.; Sears, P.; Hu, C.; Hwang, S.-B.; Shue, Y.-K.; Sucheck, S. J. Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Bioorg. Med. Chem. Lett. 2005, 15, 2123–2128.

  50. Romero, A.; Liang, C. -H.; Chiu, Y. -H.; Yao, S.; Duffield, J.; Sucheck, S. J.; Marby, K.; Rabuka, D.; Leung, P. Y.; Shue, Y. -K.; Ichikawa, Y.; Hwang, C. -K. An efficient entry to new sugar modified ketolide antibiotics. Tet. Lett. 2005, 46, 1483–1487.

  51. Yao, S.; Sgarbi, P. W. M.; Marby, K. A.; Rabuka, D.; O’Hare, S. M.; Cheng, M. L.; Bairi, M.; Hu, C.; Hwang, S.-B.; Hwang, C.-K.; Ichikawa, Y.; Sears, P.; Sucheck, S. J. Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents. Bioorg. Med. Chem. Lett. 2004, 14, 3733–3738.

  52. Lee, L. V.; Bower, K. E.; Liang, F. S.; Shi, J.; Wu, D.; Sucheck, S. J.; Vogt, P.K.; Wong, C.-H. Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides. J. Am. Chem. Soc. 2004; 126, 4774–4775.

  53. Agnelli, F.; Sucheck, S. J.; Marby, K. A; Rabuka, D.; S. -L., Yao; Sears, P. S.; Liang, F.-S.; Wong, C. -H. Dimeric aminoglycosides as antibiotics. Angew. Chem. Int. Ed. 2004, 43, 1562–1566.

  54. Sucheck, S. J. and Shue, Y.-K. Combinatorial synthesis of aminoglycoside libraries. Curr. Opin. Drug Discovery and Development 2001, 4, 462–470.

  55. Sucheck, S. J.; Wong, C.-H. RNA as a target for small molecules. Curr. Opin. Chem. Biol. 2000, 4, 678–686.

  56. Sucheck, S. J.; Wong, A. L.; Koeller, K. M.; Boehr, D. D.; Draker, K.-A.; Sears, P.; Wright, G. D.; Wong, C.-H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes. J. Am. Chem. Soc. 2000, 122, 5230–5231.

  57. Sucheck, S. J.; Greenberg, W. A.; Tolbert, T., Wong, C.-H. Design of small molecules that recognize RNA: Development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences. Angew. Chem., Int. Ed. 2000, 39, 1080–1084.

  58. Cagir, A.; Tao, Z.-F.; Sucheck, S. J.; Hecht, S. M. Solid phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A5 Bioorganic Med. Chem. Lett. 2003, 11, 5179–5187.

  59. Sucheck, S. J. Study of naturally occurring nucleic acid interactive agents. 1998, 205 pp.

  60. Chen, J.; Zhang, Y.-H., Wang, L.-K.; Sucheck, S. J.; Snow, A. M.; Hecht, S. M. Inhibitors of DNA polymerase β from Schoepfia Californica. Chem. Commun. 1998, 2769–2770.

  61. Katono, K.; An, H.; Aoyagi, Y. Overhand, M.; Sucheck, S. J.; Stevens, W. C. Jr.; Hess, C. D.; Zhou, X.; Hecht, S. M. Total synthesis of bleomycin group antibiotics. The total synthesis of bleomycin demethyl A2, bleomycin A2 and decarbamoyl bleomycin demethyl A2. J. Am. Chem. Soc. 1998, 120, 11285–11296.

  62. Sucheck, S. J.; Ellena, J. F.; Hecht, S. M. Characterization of Zn(II).deglycobleomycin A2 and interaction with d(CGCATGCG)2. Direct evidence for minor groove binding of the bithiazole moiety. J. Am. Chem. Soc. 1998, 120, 7450–7460.

  63. Skrzypczak-Jankun, E., Sucheck, S., Smith, D.A. 4-Methyl-3,5-dioxopiperazine acetic acid and 4-methyl-3,5-dioxopiperazine-N-methylacetic amide. Cambridge Crystallographic Data Centre, deposition no. CCDC 118966/CCDC 118967, 1999.

  64. Smith, D. A., Sucheck, S.; Cramer, S.; Baker, D. Nitrilotriacetamide: Synthesis in concentrated sulfuric acid and stability in water Synth. Commun. 1995, 25, 4123–4132.

  65. Cramer, S.; Sucheck, S. J.; Skrzypczak-Jankun, E.; Smith, D. A. Facile synthesis of substituted nitrilotriacetamides. Tetrahedron Lett. 1992, 33, 7765–7768.

  66. Sucheck, S. J.; Pinkerton, A. A.; Smith, D. A. Characterization of [Pb(NO3)(ntam)2]NO3 the first metal complex of the neutral tetradentate ligand nitrilotriacetamide (ntam). J. Chem. Soc., Chem. Commun. 1992, 367–368.

Patents and Patent Applications

UT Docket D2014-20: Amorphous Polyester from Bio-Based Bis-Furan Assembly. Inventors: Giatonde, V.; Sucheck, S. J. US Patent Appln. 14/621,520 Filed: 2-13-15.

UT Docket D2012-01: Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby. Inventors: Talan, R. S.; Karmakar, P.; Sucheck, S. J. US Patent: US 8,895,869 B1. Nov 25, 2014.

UT Docket D2012-14: PCT Application. Xeno-antigen-Displaying Anti-Cancer Vaccines and Method of Making. Inventors: Sucheck, S. J.; Wall, K. A.; Sarkar, S. PCT Application No. PCT/US13/026271. Filed: 2-15-2013. US 14/378,805 Filed 8-14-2014. Last US Office Action 05-05-2015.

Bifunctional Antibiotics. Sucheck, S. J. and Wong, C.-H. U.S. Patent 6,921,818. Filed: 07-26-2005.

Processes for the preparation of glycoconjugates of the breast cancer antigen Globo-H. O. Srivastava, O.; Srivastava, G.; Liang, C.-H; Yao, S.; Rabuka, D.; Wacowich-Scarbi, S.A.; Sucheck S. J.; Ichikawa. Y. 60/655,311. Filed: 02-22-2005.

Novel Antibacterial Agents. Liang, C.-H.; Duffield, J.; Romero, A.; Chiu, Y.-H.; Rabuka, D.; Yao, S., Sucheck, S. J.; Marby, K. A.; Shue, Y.-K.; Ichikawa, Y.; Hwang, C.-K. WO 2004/080391. Filed: September 23, 2004.

New aminoglycoside antibiotics as novel anti-infective agents. Liang, C.-H.; Marby, K. A.; Rabuka, D.; Romero, A.; Sgarbi, P. W. M.; Sucheck, S. J.; Shue Y.-K; Yao S. U.S. Patent 10/606,700. Filed: 06-26-2003.