We are pleased to highlight three recent publications from the Sucheck Group describing the synthesis and antigenicity of a Pseudomonas aeruginosa Psl pentasaccharide–CRM197 conjugate vaccine, the development of trehalose–Pks13 inhibitor conjugates targeting mycobacteria, and the discovery of benzoxazole-based Pks13 inhibitors for antimycobacterial drug discovery.
We are pleased to highlight three recent publications from the Sucheck Group describing the synthesis and antigenicity of a Pseudomonas aeruginosa Psl pentasaccharide–CRM197 conjugate vaccine, the development of trehalose–Pks13 inhibitor conjugates targeting mycobacteria, and the discovery of benzoxazole-based Pks13 inhibitors for antimycobacterial drug discovery.
A big thank you to the Karunarathne, Martin, Sprague, and Payton groups, along with their students, for making the magic happen with a glycosylphosphatidylinositol (GPI) anchor mimic prepared by our talented PhD candidate, Ms. Chloe Sebilleau. 🌟
Check out the study here: https://lnkd.in/gpK73Fh7
This work presents a novel labeling method to incorporate protein-based sensors at the cell surface of intact cells, demonstrating its application to probe cell surface signaling.
The Sucheck Group presented multiple posters and talks at the 17th Midwest Carbohydrate and Glycobiology symposium https://s.wayne.edu/mcgs/ at Wayne State University, Detroit Michigan.
The Sucheck Group presented multiple posters and talks at the National ACS meeting in Chicago.
The group celebrating Dr. Anshupriya Si’s and PhD graduate Alex Landgraf’s last days in the lab. Last month we celebrated Dr. Nur-E Alom’s last week. Best wishes.
The lab would like to congratulate Alex Landgraf on his successful PhD defense. Alex will move on to start a T32 Postdoctoral fellowship at Indiana University School of Medicine.
The group traveled ‘virtually’ to the University of Michigan to present their work on Mycobacterium tuberculosis GlgE inhibitors. A link to the event can be found here. http://www.umich.edu/~nagornyp/MCGS2020/index.html
Congrats to Dr. Ajith Karunarathne on funding of his NIH R01 proposal, Optical Control of Endogenous G Protein Coupled Receptor and G Protein Signaling. The 3-year grant also involves funding of a collaboration with the Sucheck lab related to synthetic aspects of new photoligands for in vivo applications.
Happy to share former PHD student Dr. Abhishek Vartak has accepted a job at Pfizer as a Senior Scientist in the Early Bioprocess team, a part of the Vaccine development division. Best wishes in the future
In January we received an award for our multi PI grant titled “Methods to Synthesize Oligosaccharide-Fusion Protein Conjugates and Enhancement of their Antigenicity”. The scope of the project includes oligosaccharide, protein, and adjuvant synthesis. The components will combined and evaluated as antibacterial vaccines. The 2.3 million dollar grant, awarded over 5 years, supports research in the Sucheck group as well as research in the groups of Prof. Katherine Wall and Prof. Erin Prestwich.
